![]() (1976) Prediction of creatinine clearance from serum creatinine. J Clin Oncol 7:1748-1756.Ģ) Cockcroft DW, Gault MH. (1989) Carboplatin dosage: prospective evaluation of a simple formula based on renal function. Referencesġ) Calvert AH, Newell DR, Gumbrell LA, et al. When using the creatinine clearance estimation there is also the consideration to be made that fluctuant serum creatinine values should not be taken in consideration because they don’t provide reliable results employed later in estimating GFR and in the Calvert formula. Target AUC usually has values around 4-7 mg/ml/min in clinical practice for already treated patients but for those without previous chemotherapy sessions the target should revolve around 6-8 mg/ml/min. This is said to be a more specific method than that of dosing based on body surface area. The carboplatin dosage value is calculated by taking into account the target area concentration versus time curve and estimated GFR. ■Carboplatin dose based on the Calvert formula is:ĭosage = Target AUC x (GFR + 25) Carboplatin and target AUC ■ The calculation of the ideal body weight by Devine’s formula: ■ If the serum creatinine is expressed in µmol/L then:ĬrCl for male = / (Serum Creatinine in µmol/L)ĬrCl for female = / (Serum Creatinine in µmol/L) ■ If the serum creatinine is expressed in mg/dL Cockcroft and Gault equation is:ĬrCl for male = / (Serum Creatinine in mg/dL * 72)ĬrCl for female = / (Serum Creatinine in mg/dL * 72) Here are the formulas that use your data: Where needed the results will be converted in both types of units for your convenience, for instance at ideal weight by Devine’s formula (from kg to lbs using 1 kg = 2.20462262 lbs). This Carboplatin AUC calculator will then retrieve you some useful indicators about the kidney function, the GFR value, the ideal weight and the total dosage required in the used case. There are fields that you need to complete for the results to be consistent such as the gender, age, weight and height in either metric or English measurements and the serum creatinine level either in mg/dL or µmol/L. The formulas used are gender specific: CrCl for men (140 - age) x Weight in kg / (Serum Creatinine in mg/dL x 72) CrCl for women (140 - age) x Weight in kg x 0. The CrCl calculator requires the patient’s gender, age, height and weight and the serum creatinine. This is a health tool that allows you to compute the total Carboplatin dose in mg based on the estimated creatinine clearance level from the Cockcroft Gault equation and on the targeted AUC value. The most common method to determine it is via the Cockcroft Gault equation. Doses of some drugs may need to be adjusted.Ĭomplete and accurately timed urine collections are essential.How does this Carboplatin AUC calculator work? ![]() This may indicate acute or chronic kidney disease. Reduced creatinine clearance is an indicator of reduced glomerular filtration rate (GFR). Measured creatinine clearance is of particular use in patients with extremes of body size or composition where estimation formulae may be unreliable. Typically falling approx 0.5 mL/min per year at ages over 30 years.Ĭreatinine clearance is a marker of glomerular filtration rate (GFR). The patient should not eat meat at the meal immediately prior to, or during, the procedure.Ī calculated value using serum and urine creatinine.Ĭreatinine clearance (mL/min) = urine creatinine (mmol/L) x urine volume (mL) x 16.7 / plasma creatinine (mmol/L) x duration of collection (hours) The patient's height and weight may be measured so that surface area can be calculated and creatinine clearance adjusted to the 'standard' body surface area of 1.73m 2 if required.Ĭreatinine clearance may be estimated rather than measured -see Creatinine clearance Cockcroft and Gault. Serum and timed urine collection for creatinine measurements see Creatinine urine.
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